{"id":18,"date":"2026-09-02T11:30:39","date_gmt":"2026-09-02T03:30:39","guid":{"rendered":"https:\/\/hmnprc.tcu.edu.tw\/?page_id=18"},"modified":"2026-09-16T06:26:12","modified_gmt":"2026-09-15T22:26:12","slug":"%e5%af%a6%e9%a9%97%e5%ae%a4%e7%b0%a1%e4%bb%8b","status":"publish","type":"page","link":"https:\/\/hmnprc.tcu.edu.tw\/?page_id=18","title":{"rendered":"Research Platform"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The Center\u2019s bioactivity-assay platform integrates rapid<em> in vitro<\/em> cell model and <em>in vivo<\/em> zebrafish screening with complementary <em>in vivo<\/em> rodent models to systematically evaluate the efficacy, safety, and underlying mechanisms of medicinal plants, natural products, and their active constituents.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/hmnprc.tcu.edu.tw\/wp-content\/uploads\/2026\/09\/animal_models.png\" alt=\"In vitro cell models and in vivo mouse, rat, zebrafish, and Drosophila models used in bioactivity assays\"\/><figcaption class=\"wp-element-caption\">Cell-based screening and complementary animal models used by the Center.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><em>In vitro<\/em> Cell Models<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Controlled and reproducible cell-based screening to elucidate pharmacological mechanisms prior to whole-organism evaluation.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cell Viability &amp; Cytotoxicity: <\/strong>Assessment of basic cellular safety, proliferation, and dosage toxicity.<\/li>\n\n\n\n<li><strong>Antiviral &amp; Antitumor Profiling:<\/strong> Functional screening for targeted bioactivity against viral and cancer models.<\/li>\n\n\n\n<li><strong>Neuroprotection &amp; Cognitive Health:<\/strong> Cellular models evaluating neurodegeneration mechanisms and neuronal survival.<\/li>\n\n\n\n<li><strong>Bone Metabolism &amp; Cellular Remodeling:<\/strong> Assays targeting osteoblast\/osteoclast activity and skeletal health markers.<\/li>\n\n\n\n<li><strong>Molecular &amp; Safety Evaluation:<\/strong> Deep-dive mechanistic pathway analysis and biomarker expression profiling.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><em>In vivo<\/em> Animal Models<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Complementary animal systems providing translational validation across efficacy, safety, and pharmacology.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mice:<\/strong> Mammalian models for disease pathobiology, therapeutic efficacy, and preclinical validation.<\/li>\n\n\n\n<li><strong>Rats:<\/strong> Specialized models for pharmacokinetic, metabolic, and systemic disease studies.<\/li>\n\n\n\n<li><strong>Zebrafish:<\/strong> High-throughput whole-organism screening, phenotype-based assays, and live imaging.<\/li>\n\n\n\n<li><strong><em>Drosophila<\/em>:<\/strong> High-tractability genetic models for functional mechanism mapping and pathway analysis.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Research Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neurodegeneration, Memory &amp; Sleep Disorders<\/li>\n\n\n\n<li>Antiviral &amp; Antitumor Therapeutics<\/li>\n\n\n\n<li>Bone &amp; Metabolic Health<\/li>\n\n\n\n<li>Retinal Degeneration &amp; Mitochondrial Function<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The Center\u2019s bioactivity-assay platform integrates rapid in vitro cell model and in vivo zebrafish screening with complementary in vivo rodent models to systematically evaluate the efficacy, safety, and underlying mechanisms &#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18"}],"version-history":[{"count":5,"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":130,"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/18\/revisions\/130"}],"wp:attachment":[{"href":"https:\/\/hmnprc.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}